Nagisa Misumi and Honoka Yukishiro couldn't be more different. Nagisa is sporty and Honoka bookish, and while they attend the same school, they have very little in common - until one day, a shower of shooting stars brings two very unlikely visitors into their lives: Mippuru and Meppuru, refugees from the Garden of Light, which has been conquered by Darkness. Endowed with new and startling powers, Nagisa and Honoka become Cure Black and Cure White, magical defenders of the light - together, they are Futari Wa Pretty Cure.
After the Queen was dangerously wounded from the fight with Evil King, she separates into the parts that make her. It is now up to Nagisa and Honoka to become Cure Black and White again after Mepple and Mipple awaken once more as someone attempts to resurrect the Evil King.
The girls try to learn more about the mysterious Hikari while searching for the missing Heartiels.
After Pollun runs off to locate Seekun, he and Hikari run into one-another. When he takes off she decides to follow after him and learns something about her new friends...
Hikari tries to determine just who or what Pretty Cure is as Nagisa tries to find another solution to deal with her noisy room guests without alerting anyone of their presence. In this time, Hikari and Pollun express a desire to help the Cures out.
Cure Black and Cure White welcome their brand new teammate, Shiny Luminous and help her adjust to her newfound abilities. In this time they start wondering what Hikari's connection with the Queen is.
Akane sends Hikari shopping with Nagisa and Honoka and Hikari gets temporally lost. She manages to get the shopping done and join up with Nagisa and Honoka again but they are attacked by Uraganos on the way back.
Nagisa's Mom goes to her high-school reunion and leaves Nagisa to do the chores. Nagisa slacks off at first but then gets to it after a visit from Honoka.
Nakao, Akane's colleague, tells her to close the Tako Cafe and return to her original job. She becomes worried and Hikari, Nagisa and Honoka helps her not to close the café.
It's Honoka's birthday and her parents come to visit her after being away for their jobs. They take her to a French restaurant but the power gets cut off and Viblis attacks.
Honoka and Nagisa's class goes on a field trip to a cake factory but are attacked by Viblis.
It's the Lacrosse Championship and the team are set to take on another school. But a fallout with two of the members causes the team to lose, but Nagisa manages to make them work together. Meanwhile, Hikari gets an encounter with Viblis but is not able to fight her herself. Later on, Honoka and Nagisa comes to the rescue and tells Hikari not to fight the Dark Zone alone
Nagisa has an argument with her mother and feels that she is annoying. But after a conversation with her father, she realises all the trouble that her mother has gone through to look after Nagisa, so she goes home to make an apology.
Fujipi's soccer team has a match with another school and Nagisa, Honoka and Hikari go to cheer him on. But Circulas appears in the middle of the match, so they leave the game to prevent the match from being disrupted by him.
Hikari goes out with her friends Nao and Miu. Meanwhile, Honoka studies at a library whilst Nagisa goes to a bakery to get bread for her mother. They all meet up at the same area and Nao persuades Nagisa into playing basketball with some boys.
Shiho and Rina tell Nagisa that her horoscopes predicts a good week for her and that her lucky colour is yellow. Nagisa does not believe it, but after a series of good events, she decides to not study for her mid-term exams and instead rely on her luck. During the test, Uraganos attacks, and Nagisa, Honoka and Hikari fight him.
The Science Fair is coming up and Honoka and the Science Club do not know what theme they should do for the fair so they redo the Lightning theme that we done last year (as seen in Pretty Cure). Honoka feels that it is not the right choice but after a while, she changes the theme to "Trash and Us" and everyone works hard on it. On the day of the Science Fair, Uraganos attacked Honoka and Yukiro but Nagisa and Hikari made it on time to fight him off.
Nagisa's family and Honoka go on a camping trip, and Hikari joins them later on. Chuutaro runs away, and the three girls chase after him, only to find Uraganos. They fight him off and return to Nagisa's parents, but they could not go to the waterfall because Nagisa's dad was concerned about the rain. When they visit Akane, they find out that a landslide happened by the waterfall. Intelligen gives Nagisa, Honoka and Hikari some notepads and goes inside the Chairect.
When Nagisa overhears her father talking about moving to Osaka, she feels worried about Honoka and Hikari's reaction to the news. Fortunately, it was her father's boss who was moving, but Hikari thinks that Nagisa is moving and finds it hard to tell Honoka.
After noticing how strange Rina has been the girls discover she has been taking care of a baby raccoon. As she tries to adjust to saying goodbye to it, Nagisa and Honoka are overwhelmed by their own sadness when they realize that one day they will have to part with Mepple and Mipple.
Hikari bonds with a boy named Daiki and tries to help him feel better after he reveals he got into a dispute with his parents. Meanwhile, the boy in the mansion is finally allowed outside of the Mansion of Darkness.
Pretty Cure is confronted by the toughest villain yet, Baldez...
The girls go to Lake Hyoutan with Seekun and Intelligen to look for the 'shining piece of Earth surrounded by six pillars'. But when Baldez figures out their plans he steps in to take it and the Power of Creation for himself.
Nagisa and Honoka are preparing to lead their summer camp teams, but to their surprise, Hikari decides to join. Along with Yuka - who doesn't actually seem to be there for the clubs themself
The girls, along with Honoka's grandmother, decide to visit the lake one warm summer day. Seeing that Hikari has a problem, Sanae encourages her to never give up and she uses this advice when the girls get attacked by Viblis.
As the Summer Festival approaches, Nagisa worries over not having a plan for the future. Unknowingly, someone else she knows is in the same boat as she is and with that persons help, she may realize that she doesn't need to hurry.