Dormant, experimental cells begin to awaken inside their human hosts, turning them into creatures called 'Amazons'. Two Amazons—Jin Takayama and Haruka Mizusawa—transform into Kamen Riders Alpha and Omega, aiming to exterminate the growing threat.
Haruka Mizusawa, Kamen Rider Amazon Omega, heads back into town. Returning from exile after Operation Tlaloc. He has found a new target in Iyu, who is a Sigma Type Amazon.
Squad 4C takes extreme measures against Chihiro to find out more about his origin; Iyu heads toward the fun place that Chihiro told her about, where she encounters the one who wants to put an end to all Amazons.
As Jin finally met Chihiro, all past events prior to Chihiro's birth and what came after Tlaloc alongside Jin and Haruka's war had finally been revealed.
Chihiro is no longer only targeted by 4C, but by Jin as well. Unwilling to submit to his fate, Chihiro fights with Haruka.
Jin confronts Nanaha on his own. The extermination squad faces off with Mamoru... They all must fight in order to tie the loose ends in these stories. Chihiro and Iyu struggle to keep hold of their humanity in their little remaining time.
The Nozama Peston Service are able to recover an undissolved Amazon, which they deliver to Nozama Pharmaceuticals for research. Haruka struggles to find his own reason to fight, and so turns to Jin for answers.
Haruka joins forces with the Nozama Peston Service, who are trapped inside an apartment complex, surrounded by 183 Ant Amazons.
A number of Amazons have been awakening in one specific area - a closed down restaurant. The Nozama Peston Service go undercover to investigate. Meanwhile, Tachibana's plans come to fruition.
A storm is coming, and Jin moves to ensure that Operation Tlaloc is carried out. The Nozama Peston Service quickly find themselves overrun by a mass awakening of Amazons.
Three weeks have passed since Operation Tlaloc. As Nozama Pharmaceuticals continues to clean up the wreckage, the surveillance team goes missing...
A group of youths, under the moniker 'Team X' are hunting down Amazons. Leading the charge is a mysterious blue Amazon, Neo.
Chihiro, who was brought back to 4C, wants to exterminate the Amazons with Iyu. In the battle with no emotions and only pain, Chihiro transforms to protect someone for the first time.
Thinking about Chihiro finally begins moving Iyu's heart. However, the harsh pain she will have to endure once she comes back to reality will be unbearable... In the meantime, Jin and the extermination squad also have various painful experiences heading their way.
By Kurosaki's order, Iyu is able to once again start hunting Chihiro. While on the run, Chihiro becomes incapable of suppressing his Amazon instincts. Those around him are no longer moved by the youngster's desire to live.
Chihiro, confronted with the reality of being "the Original", decides to sacrifice himself to save Iyu, who had been taken hostage. Haruka and Shido encounter a mysterious Amazon in a place which they considered to be Mamoru's hideout.
Haruka Misuzawa (Kamen Rider Amazon Omega) continues his search for Mamoru, the Mole Amazon. HE soon encounters the extermination team, including Chihiro (Kamen Rider Amazon Neo) and Iyu, the Crow Amazon. Meanwhile, something strange is happening at the hospital where Emiri was admitted.
As Mamoru (Mole Amazon) confronts his comrades from the past, Mizuki Mizusawa again encounters Haruka Mizusawa (Kamen Rider Amazon Omega). Can the 5 years which has separated them be filled?
Chihiro wishes to act more human. He leaves the 4C compound to spend time with Iyu. Makoto Shido begins investigating an important incident, and encounters a person who he never thought he'd meet again…
When the Shrike Amazon escapes, the Nozama Peston Service goes in pursuit. But all is not as it appears in this murder case.
Asked to leave the Nozama Peston Service, and fearing being caged once more at home, Haruka runs away. A disappearing Amazon signal sends the remaining Nozama Peston Service members out on the hunt.
With the mass awakening of Amazons, the Nozama Pharmacy executives hold a board meeting. The Nozama Peston Service are sent to an apartment building to deal with an Amazon infestation.
Narrowly escaping death at the hands of the newest Amazon, Sigma, Jin meets with the Nozama Peston Service to trade information and reveal a shocking secret.
Haruka is fatally wounded following his fight with Sigma, and Operation Tlaloc is nigh. Who will walk away from the killing day?
With a green Amazon entering the fray, the red Amazon - Alpha - aims to capture him. The Nozama Peston Service are tasked with hunting down a Dragonfly Amazon - one of their own team.
A professional extermination team, the Nozama Peston Service, are deployed to hunt flesh-eating organisms called Amazons, which are slowly appearing across the city.
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