Spooky Kitarō focuses on the young Kitarō—the last survivor of the Ghost Tribe—and his adventures with other ghouls and strange creatures of Japanese mythology. Along with: the remains of his father, Medama-Oyaji (a mummified Ghost tribesman reincarnated to inhabit his old eyeball); Nezumi-Otoko (the rat-man); Neko-Musume (the cat-girl); and a host of other folkloric creatures, Kitarō strives to unite the worlds of humans and Yōkai.
A strange masked youkai is attacking groups of young people who then go missing. Kitaro begins to investigate the string of incidents. Just then, Mana gets caught up in the masked youkai's attack. Kitaro races in and manages to save Mana, but the other young people are kidnapped. Upon investigating the cell phones left behind at the scene, Cat-girl discovers that each of the victims has a picture of a certain camphor tree. Kitaro and the others head to the tree, but it's already been cut down. They hear a story from an old man named Kawaji. He says that the youkai is the guardian spirit of the camphor tree and the young people are getting what they deserve. Who is the masked youkai and what is he after...?!
On the run after robbing a convenience store, Kakeru happens upon a strange bus. To escape the police, he reluctantly boards the bus and asks where it's headed. The driver simply replies, "to the place you are meant to go." The bus ends up somewhere so eerie it hardly seems part of our world. Frightened by the scene, Kakeru speaks to one of the passengers who tells him, "we have been chosen to be sent to Hell while still living." Overwhelmed by terror, Kakeru tries to stop the bus, but the bus doesn't stop. In a frenzy, Kakeru jumps out a window of the bus, but...!?
Using Rei and Ibukimaru's techniques, and Cat-girl's life, a portal is opened to another dimension. Mana searches for Kitaro, racing into that place which is neither this world nor the other. Finally, she catches sight of Kitaro, but...!? Meanwhile, moment by moment, the earth is pushed closer to the tipping point by Backbeard. How will this war end, and will Kitaro return?!
A ticket to a play arrives for Kitaro from a man named Hongou, a world-famous director. The play is based on a case Kitaro solved and set in a locale from Hongou's youth. It's called "A Foggy Night in Angkor Wat." Fifty-two years ago in Angkor Wat, a young woman would be kidnapped by ghosts every four years. Kitaro went there to resolve the problem and met Hongou and his wife Sara. They laughed, dismissing the incidents as rumors, but that night, Sara was kidnapped by ghosts. Kitaro saved Sara, and the case was closed, but when Kitaro sees Hongou again he tells him something - "The case isn't over yet..."
Chasing the last of the Four Generals of Betrayal, Tamamo-no-mae, Kitaro finally comes face-to-face with her in Hell. But, Tamamo-no-mae disappears without settling things with Kitaro and the others. Kitaro wants to chase after her right away, but Isurugi Rei stands in his way. Rei desires even more power, and attacks Kitaro! As Hell begins to crumble, will Kitaro be able to defeat Rei and capture Tamamo-no-mae?!
One day, Mana and her mother go to visit Toshiko, Mana's hospitalized great aunt. When they arrived at the hospital, Toshiko asked if they could check on the flowers at her home. When they reached the house, Mana was surprised by the sight. Bright red flowers were in bloom everywhere; from the garden to the walls and the roof of the house. Mana sent pictures of these mysterious flowers to Neko-Musume. While Mana listened to stories about her great aunt from her mother, Kitarō and the others soon arrived. Medama-Oyaji explained that these flowers were called Yōka and bloom from yōkai activity or spiritual power. Why are they at Toshiko's house? Mana joins Kitarō and the others as the head toward a southern island to discover the Yōka's origins.
When he learns that Mana and Isurugi Rei have met, Kitaro grows even more wary. On the way back from GeGeGe Forest, one of the Four Generals of Betrayal, Kidou, Ibukimaru, appears before Mana and Cat-girl. He calls Mana a vessel and kidnaps her. Kitaro starts searching for her immediately, but, unfortunately, requests start pouring in. All of them are about the ghost of a headless woman appearing at the dam. Kitaro asks Kagami-jiji and the others to handle Mana's case for a little while and heads to the dam, but when he gets there he's attacked by Ibukimaru. Then, Rei shows up...!?
Mana is hungry after the school's opening ceremonies, so when her friend Aya mentions her parents run a cafe, Mana goes over to her house. The cafe is quite impressive, but there are no customers. Mana finds a god of poverty, Bimbougami, on the premises. At first, Aya can't believe it, but as soon as she sees it, she asks Kitaro to get rid of it. Bimbougami says his presence is maintaining the peace in their family, but Aya refuses to listen. She presses Bimbougami to get out. After Bimbougami leaves, Aya meets a mysterious child in town. Who is this child? And what is the truth behind Bimbougami's words?!
A client, Youko, says her hands have been "stolen." On her neck are clear marks from where she strangled herself with her own hands. Daddy Eyeball believes it's the work of Te-no-me, but he has some doubts because Te-no-me is a youkai that usually only plays pranks. A string of suspicious deaths begins. Kitaro realizes that all the victims had their hands "stolen" by Te-no-me just like Youko. In the midst of Kitaro's confusion, Nurarihyon appears before him. What could Te-no-me's aim be? And what are Nurarihyon's motives?
Kitaro receives a request from a photographer named Kunou who says he's being haunted by a ghost. That night, Kitaro accompanies him to where he's supposed to meet someone, and the ghost of a woman swoops down on Kunou. Kitaro dodges the attack and sees that the ghost is a youkai that attached itself to a corpse, a mouryou. When he asks if the Kunou knew the woman whose corpse the mouryou has possessed, Kunou shakes his head in denial. Suspicious of his reaction, Kitaro searches for the truth, heading to Mukuromura where the mouryou lives. Who was the dead woman? And why is the mouryou attacking Kunou?!
An abandoned town in north-east Japan. When night falls there, eerie black clouds rise and from them resounds a terrifying cry. Everyone who hears it falls ill and becomes unable to move. Kitaro receives a letter from Kanji, a boy who lives there, and heads for the town immediately. A mysterious man watches Kitaro from afar...!?
King Enma demands that Kitaro apprehend the nine-tailed fox, Tamamo-no-mae. The spirits of the Four Generals of Betrayal are necessary to maintain the balance of spiritual energy in Hell. There can be no more delay. Amidst all this, the Plastered Wall and Child's-cry Old Man haven't returned from trying to resolve the request that came in a letter, and the Sand-throwing Hag, who went to look for them, has disappeared too... Meanwhile, a battleship approaches a certain area of Japan. Behind these events, a beautiful, eerie woman is pulling the strings...?!
Something is causing groups of people to mysteriously age, and each of the victims used a rejuvination cream labelled "Beauty B Beauty." To try to bring the situation under control, Kitaro and the others head to the island where the youkai Nuppeppou is manufacturing the cream. But as soon as they land, they hear a strange song and their bodies begin to age. As they stand there bewildered, the Sand-throwing Hag starts behaving strangely. Though she pretends to know nothing, a jar of "Beauty B Beauty" cream falls out of her sleeve! What is Nuppeppou trying to accomplish? And what will happen to the Sand-throwing Hag...?!
Kitaro begins to wonder if it was Nurarihyon who released the Four Generals. In his plan to restore the power of youkai, he uses brute force, and Kitaro steels his vigilance against him. Meanwhile, Shu-no-bon releases the seal on a certain mound. Nurarihyon is moving again. Kitaro receives a request to look into a town where people are disappearing one after another and heads there with Cat-girl. When they arrive, they find no people, only cats. Finding both the state of the town and the fact that their client doesn't appear suspicious, Kitaro and the others spot a huge cat youkai and follow it into a cave. What they see there is...!?
The world ended on February 29th. In the ruins of Tokyo, gravely wounded Cat-girl and Daddy Eyeball are surrounded by people who have turned into vampires. "This is the end, Cat-girl..." Looming over her, a vampiric Kitaro and Mana. Though the people dearest to her are right in front of her, there's nothing Cat-girl can do. Daddy Eyeball steels his will and summons the Phantom Train. It's a train that can only be called once, at the cost of Daddy Eyeball's life. As Cat-girl jumps aboard, Daddy Eyeball says, "Save the world... Save Kitaro, please..." and then he's engulfed by flames. Where will the Phantom Train take Cat-girl...?!
Hiderigami loves manga, loves it so much that he's trying to draw some himself. He takes his finished manuscript to several different publishing companies, but his frightening appearance prevents anyone from accepting it. When he asks Kitaro to go in his place, Kitaro declines. One day, he meets Kakutomi, an associate editor at Weekly Shounen Machine-gun. He does not reject the manuscript on the basis that Hiderigami is a youkai, instead, after evaluating it, he gives Hiderigami guidance on editing it. Hiderigami starts out in high spirits, but every page needs correction. After who knows how many corrections, Hiderigami grows angry. Confronted with the enraged Hiderigami, Kakutomi...!?
On the mountains where no one can enter lives a god called Taitanbou-sama. The watchman of the mountains has the duty of going to the sacred rock every four days and praying that no one other than the villagers may enter the mountains. It is said that if the watchman ever shirks in this duty, a terrible curse will befall the village. The Agata family has served as watchmen, but Kenta, born into that family, tries to break the sacred rock in an attempt to escape his duty. He and his friends try to go into the mountains, but Kitaro and his father stop them. That night, undeterred, Kenta goes to try to break the stone again, but Kitaro appears and warns him of the curse. What is the truth Kitaro speaks of events from 13 years ago...?!
In the year 1968, an apartment was built. However, there were three yōkai living there despite the new construction. These yōkai were revealed to be Rokuro-Kubi, Akaname and Karakasa. Tenants were scared away one after another. The couple who owned the apartment were at a loss, until they decided to write a letter to the Yōkai Post... In present day, Natsumi, the granddaughter of the apartment owners, lived in the old apartment alone. She was set on tearing the apartment down to live with her fiancé, but Kitarō soon arrived. Kitarō talks about the history of the apartment, and asks Natsumi to reconsider its demolition.
One day, on her way home from school, Mana talks with her friends about how a new social networking app, Omega Talk, has gotten popular. On the app, the videos on Charatomi's yokai channel are super popular. Mana is happy to hear her friends describe youkai as cute. Meanwhile, Kitaro is looking for a youkai said to be stealing babies. Kitaro uses Child's-cry Old Man as a lure, and waits. The youkai Ubume appears and kidnaps Child's-cry Old Man. Kitaro hops on Cotton Cloth's back and chases Ubume. Little do they know, the chase is being broadcast on the youkai channel...!
Mana uses her power to obliterate Cat-girl body and spirit. Footage of it is broadcast and the antagonism between youkai and humans intensifies. Both sides carry resentments, and as they each seek to destroy the other, Kitaro seeks out Mana to learn the truth of things. Meanwhile, Mana hears about her bloodline and her maternal great-grandmother. It was that great-grandmother who gave her her name, and she also had the same kind of connection to the unseen world. Kitaro appears. Mana's rage over her mother's hurt and Kitaro's rage over Cat-girl's obliteration clash. What will happen to these two who stand in the space between humans and youkai...?
A rumor silently spreads on the internet, that Yamata no Orochi on Mount Oguro with grant any 8 wishes. Hearing this, Kitaro goes to hear the details from Yobuko, who knows everything that goes on in the mountains. Meanwhile, Saitou, who laments his terrible luck, hears the rumor. He immediately heads for Mount Oguro where he meets the uncanny Yobuko. When Yobuko hears that Saitou wants to meet Yamato no Orochi, she passes him a large diamond. It begins to shine brightly, and before he knows it, Saitou is sealed inside it. Face-to-face with the enormous Yamato no Orochi, Saitou tries desperately to run away. Then, Yamato no Orochi...!?
All around Mana, humans are being stricken with a strange illness that turns them all wrinkly and causes them to fall unconscious. She notices that her classmate Tsutomu is acting oddly, but he keeps telling her to leave him alone. Worried, Mana goes to his apartment building. But, faced with his mother's piercing gaze, Mana runs away. That night, Mana tells Kitaro about Tsutomu and his mother's odd behavior. Wondering if it's somehow connected to the strange illness, Kitaro and Cat-girl go to Tsutomu's apartment. What they see there, the truth behind the illness is...?!
Kitaro is debuting as an idol?! Mana is shocked when she looks at her phone. Meanwhile, as Kitaro walks leisurely through the city, he is suddenly surrounded by women calling themselves his fans. Kitaro runs away, but the girls chase him to the ends of the earth. When he escapes back home, he finds a mountain of fan mail. Kitaro has been mistaken for the idol G Kitaro! Kitaro senses youkai energy from one of the fan letters. He goes to meet the sender of the letter, and heads to a certain harbor in the middle of the night. What does Kitaro see there? And who is G Kitaro?!
The Emperor of the European youkai has been resurrected. "There is only one path left to you. Ruin!" Backbeard has joined forces with Nurarihyon and devoured a city. It has caused humanity's loathing of youkai to increase. Anti-youkai laws are established, and the government takes out one youkai terrorist after another. Amidst all this, the youkai hatred of humans grows. The wave of feeling swamps the GeGeGe Forest and anti-human youkai begin to appear. In order to prevent humans and youkai from clashing, Kitaro goes to the prime minister, determined to bring her around.
Despite the efforts of Kitaro and the others, the battle between human and youkai intensifies! Will everything turn out the way Nurarihyon planned?!