In a major slum called La Colina, young idealist Hache and his friends will confront the drug dealers who control the neighborhood. They will succeed with the help of music, an old Chinese ninja master and a mythical character who also lives in La Colina. Simultaneously, Juana will find shelter there as she runs away from her family's assassins.
As tension escalates on the neightbourhood, Juana is not sure her secret's safe anymore, which could put her dearest ones in danger again.
After Juana loses her entire family in front of her eyes, she manages to make it out alive and assumes a new identity to go into hiding. Meanwhile, elsewhere, the leader of the band "El Cruce" is murdered after he attempted to stop a drug sale, and his brother "Hache" must take his place.
Leon throws a party at his mansion, which is only a distraction for the 2200 Band which is going on full assault that same night on the neightbourhood.
For the first time, Hache experiences that music can help fight back the violence of drug dealing on his neighbourhood. Juana starts to learn that she must make sacrifices if she's to avenge her family.
Felix arrives to the neightbourhood with a plan for Juana and the band. Hache discovers a way to find out the truth about his brother's murder. John Alex finds an new ally in the most unlikely of places.
As Hache comes into terms of being the leader of his band, Juana gets an unique opportunity: return to the crime scene and avenge her family.