The WORST episodes of Common Side Effects

Every episode of Common Side Effects ever, ranked from worst to best by thousands of votes from fans of the show. The worst episodes of Common Side Effects!

Follow Marshall and Frances, former high school lab partners who begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Last Updated: 4/14/2025Network: Adult SwimStatus: Continuing
Lakeshore Limited
star
7.86
249 votes

#1 - Lakeshore Limited

Season 1 - Episode 2 - Aired 2/2/2025

Marshall is on the run, trying to flee New York; Frances confides to her boss, Rick, about the mushroom; Rick sends her to Marshall's farm to get more, but the situation gets out of hand

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Pilot
star
7.89
312 votes

#2 - Pilot

Season 1 - Episode 1 - Aired 2/2/2025

High school lab partners Marshall and Frances uncover a conspiracy by big pharma and the government to suppress a rare mushroom that could cure all diseases

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Hildy
star
7.92
216 votes

#3 - Hildy

Season 1 - Episode 3 - Aired 2/9/2025

Marshall seeks advice from his old mentor, Hildy. Copano and Harrington are drawn further into the mystery of the mushrooms obtained at the raid.

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In the System
star
7.98
189 votes

#4 - In the System

Season 1 - Episode 6 - Aired 3/2/2025

Marshall arrives in jail and learns that some very important people refuse to let him out, while danger lurks around every corner. Frances makes a fateful decision. Copano and Harrington pick up the pieces.

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Star-Tel-Lite
star
8.06
199 votes

#5 - Star-Tel-Lite

Season 1 - Episode 5 - Aired 2/23/2025

Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.

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Blowfish
star
8.08
181 votes

#6 - Blowfish

Season 1 - Episode 7 - Aired 3/9/2025

Marshall is rescued by a fellow prisoner and is now in his debt. Frances struggles with a life-changing event.

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Dumpsite
star
8.14
198 votes

#7 - Dumpsite

Season 1 - Episode 4 - Aired 2/16/2025

Marshall buys a plot of land near a chemical waste site with a plan to grow more mushrooms; Frances rushes home from Europe after a huge development; Copano and Harrington investigate a connection between Marshall and Frances.

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Amelia and Wyatt
star
8.20
180 votes

#8 - Amelia and Wyatt

Season 1 - Episode 8 - Aired 3/16/2025

Marshall meets an old friend and forges a new plan. Frances receives terrible news and is therefore torn.

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Raid
star
8.41
186 votes

#9 - Raid

Season 1 - Episode 10 - Aired 3/30/2025

Agents from the FBI and the DEA storm the site - with tragic consequences. The fate of the mushroom is decided.

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Cliff's Edge
star
8.51
180 votes

#10 - Cliff's Edge

Season 1 - Episode 9 - Aired 3/23/2025

Marshall finds out what Hildy is up to, but still faces obstacles. Copano and Harrington get on Marshall's trail.

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