The WORST episodes of Common Side Effects

Every episode of Common Side Effects ever, ranked from worst to best by thousands of votes from fans of the show. The worst episodes of Common Side Effects!

Follow Marshall and Frances, former high school lab partners who begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Last Updated: 3/6/2025Network: Adult SwimStatus: Continuing
In the System
star
7.88
67 votes

#1 - In the System

Season 1 - Episode 6 - Aired 3/2/2025

Marshall arrives in jail and learns that some very important people refuse to let him out, while danger lurks around every corner. Frances makes a fateful decision. Copano and Harrington pick up the pieces.

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Pilot
star
7.92
190 votes

#2 - Pilot

Season 1 - Episode 1 - Aired 2/2/2025

High school lab partners Marshall and Frances uncover a conspiracy by big pharma and the government to suppress a rare mushroom that could cure all diseases

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Lakeshore Limited
star
7.92
153 votes

#3 - Lakeshore Limited

Season 1 - Episode 2 - Aired 2/2/2025

Marshall is on the run, trying to flee New York; Frances confides to her boss, Rick, about the mushroom; Rick sends her to Marshall's farm to get more, but the situation gets out of hand

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Hildy
star
7.98
128 votes

#4 - Hildy

Season 1 - Episode 3 - Aired 2/9/2025

Marshall seeks advice from his old mentor, Hildy. Copano and Harrington are drawn further into the mystery of the mushrooms obtained at the raid.

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Star-Tel-Lite
star
8.00
99 votes

#5 - Star-Tel-Lite

Season 1 - Episode 5 - Aired 2/23/2025

Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.

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Dumpsite
star
8.04
114 votes

#6 - Dumpsite

Season 1 - Episode 4 - Aired 2/16/2025

Marshall buys a plot of land near a chemical waste site with a plan to grow more mushrooms; Frances rushes home from Europe after a huge development; Copano and Harrington investigate a connection between Marshall and Frances.

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