Mark, Jesse, and Amanda are trapped in a hotel when it's quarantined after a deadly virus is released. They struggle to contain the virus, while at the same time trying to locate its origin. Meanwhile, a scheming seductress carries out her plan, using the virus as a diversion to rob a nearby bank vault.
Jesse saves a woman, Chloe, in a traffic accident that claims a jealous lover forced her off the road. Jesse looks out for his patient when her ex-boyfriend threatens her. Jesse rushes to Chloe's aid when her life is threatened by her boyfriend, and inadvertently kills him. Jesse finds himself the victim of Chloe's 'fatal attraction' as she pursues him voraciously. It gradually becomes clear that Chloe was the aggressor in her previous relationship.
Dr. Sloan investigates when an unpopular colleague drops dead while performing an operation. Mark investigates his fellow doctors when tests reveal the deceased was poisoned.