Mark, Jesse, and Amanda are trapped in a hotel when it's quarantined after a deadly virus is released. They struggle to contain the virus, while at the same time trying to locate its origin. Meanwhile, a scheming seductress carries out her plan, using the virus as a diversion to rob a nearby bank vault.
Dr. Sloan investigates when an unpopular colleague drops dead while performing an operation. Mark investigates his fellow doctors when tests reveal the deceased was poisoned.