While working late at the lab Quincy and Sam are taken hostage by syndicate chief Vincent DiNardi. He has been poisoned and wants the two medical examiners to find out how the toxin was administered. Once he knows that he can make sure arrangements are completed for his revenge before he dies.
A fire in a small motel room causes the death of the single woman occupying it. The evidence shows that the identity of the woman is Jessica Ross, the country's top newswoman. As Quincy begins a press conference confirming her death Jessica walks in through the door, declaring that the rumours of her death are unfounded. Quincy and Asten are shocked but soon Quincy doesn't believe that this woman is Ross, and that his original findings were correct. He thinks that the body was Jessica ross and this woman is an imposter.
Quincy rushes to an Arizona Native American reservation when he hears that his foster son, Chester, is suffering from bubonic plague. When he confirms this and tries to warn the local authorities he finds that they have no interest in the potential disaster. They are much more concerned with the forthcoming opening of a new country club that will bring tourists to the area. They have a big golf competition planned with many big names arriving and they don't want to cause a panic that would ruin the resort before it has even opened.
An autopsy on a college football star reveals a congenital brain disease, and Quincy urges the victim's younger brother to stay out of the next high school game. But the boy's father and the school are determined to win the championship at any cost.