Ghosts are rampaging through the city and the EGB's equipment can't stop them. But a mysterious Piper claims he can.
A Rabbi's son creates a Golem to defend against temple vandalism. But the Golem grows to strong to be controlled, forcing the EGB to come up against this violent force.
Egon builds new and improved ghost busting equipment for the new team. While they search for Achira, Eduardo again sees Kylie, who has been possessed by Achira.
Construction workers have inadvertantly released Achira, a ghost that can spread disease. The only ones who could stop this ghost are the Ghostbusters, but they have long since disbanded. In fact, only Egon is still in New York City. He is now teaching a college class, but his four students may prove very helpful against this nasty ghost.