The Powerpuff Girls throw a slumber party and invites every girl in their school to come. By the time they give their invitation out to the last girl Mojo steals it and comes to the party dressed up as Mojesha.
Ms. Bellum seduces the Mayor to get some time off, but when something seems a miss the Powerpuff Girls investigate the situation.
Mojo Jojo creates the perfect plan to destroying The Powerpuff Girls ever, but because of an open window in his home Mojo's plan's fall into the Amoeba Boys' hands.
A female villain named Femme Fatale teaches the girls' to be sexist, so she can get away with crimes.
A new villain steals valuable information from smart people in Townsville, so the Powerpuff Girls use the Mayor as his new target.
Putting everyone in the world asleep can be a hard job so to make it easier the Sandman puts the world to sleep forever.