An alien tv crew comes to Earth to film MIB agents on the job just as Drekk returns to cause trouble.
Changes abound at MIB as Dr. Zeeltor takes over in the lab for Elle, who has become a field agent and gotten partnered with an alien named Agent X. As these new changes set in, MIB has to stop New York from being devoured by a Barooga.
A super hero caling himself Cosmosis emerges to defend the city from evil, but he's really an alien looking to put his powers to good use. However, MIB feels his new profession could attract trouble for Earth, so they try to lure him out using Jay as bait.
A member of a witness protection program for aliens is on the run from an intergalatic gang called The Association when they discover he's on Earth.